Black elderberry extract inhibits influenza virus and bacteria. 

The berries of the black elder plant (Sambucus nigra L.) have been relied upon for centuries to manage cold and flu symptoms.1,2 

Black Elderberry Extract has been rigorously tested in scientific studies for anti-viral and anti-bacterial properties and efficacy against coughs, colds and flu. Studies were conducted in both laboratory settings and on human subjects. Black Elderberry Extract 3,4,5  has been demonstrated to inhibit influenza virus and bacteria. 3,4,5.

 Human clinical study with 312 subjects

Science Validation - Colds & Flu

To test the efficacy of European Black Elderberry Extract on the physical and respiratory health of long-distance air travellers, a human clinical study with 312 subjects was arranged. It was found that supplementation is significantly effective at reducing the total duration and severity of upper respiratory symptoms. 

Nutrients. 2016 Mar 24;8(4):182. doi: 10.3390/nu8040182
Elderberry Supplementation Reduces Cold Duration and Symptoms in Air-Travellers:
A Randomized, Double-Blind Placebo Controlled Clinical Trial.

Tiralongo E1,2, We SS3,4, Lea RA5



Colds and Flu Infections

Approximately 20% of  travellers have upper respiratory health problems after a long distance flights.
The immune system and overall health can be severely compromised during long-distance flights.

Human Clinical Trial Protocol

  • 312 economy class passengers
  • Dosage of 300 mg - 900 mg European Black Elderberry Extract
  • Cold episodes, cold duration and symptoms all recorded

Study results

  • 50% fewer cold episodes after European Black Elderberry Extract
  • 33% shorter illness duration
  • 50% fewer symptoms
  • 33% less severe symptoms 

Fast Facts about Colds and Flu

2018-2019 Flu By The Numbers

The Centers for Disease Control and Prevention (CDC) estimates that between October 1, 2018 and February 23, 2019 there were:

  • 20.4 – 23.6 million cases of flu 
  • 9.5 million – 11.1 million flu-related medical visits 
  • 252,000 – 302,000 flu-related hospital admissions 
  • 16,400 – 26,700 flu-related deaths 

Money Matters

  • $10,4 Billion - Estimated average of direct costs for outpatient doctor visits and inpatient hospital stays attributed to seasonal flu outbreaks  
  • 28% - Percentage of over-the-counter medication spending specifically for remedies against colds and flu
  • $16.3 Billion - Estimated lost earnings each year due to flu, as a result of 111 million missed work days 
  • $21.39 Billion - Cost to employers of lost employee productivity (2018) due to flu


  1. Blumenthal M. The ABC Clinical Guide to Herbs. American Botanical Council; 2003.
  2. Roxas M, Jurenka J. Colds and influenza: A review of diagnosis and conventional, botanical, and nutritional considerations. Altern Med Rev. 2007(12):25–48.
  3. Barak V, Halperin T, Kalickman I. The effect of Sambucol, a black elderberry-based, natural product, on the production of human cytokines: I. Inflammatory cytokines. Eur Cytokine Netw. 2001;12(2):290–296.
  4. Zakay-Rones Z, Varsano N, Zlotnik M, et al. Inhibition of several strains of influenza virus in vitro and reduction of symptoms by an elderberry extract (Sambucus nigra  L.) during an outbreak of influenza B Panama. J Altern Complement Med. 1995;1(4):361–369.
  5. Roschek Jr B, Fink RC, McMichael MD, Li D, Alberte RS. Elderberry flavonoids bind to and prevent H1N1 infection in vitro. Phytochemistry. 2009;70(10):1255–1261.
  6. E., Wee S,, Lea R., Elderberry Supplementation Reduces Cold Duration and Symptoms in Air-Travellers: A Randomized, Double-Blind Placebo-Controlled Clinical Trial. Nutrients. 2016. doi: 10.3390.

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Iprona AG developed and markets ElderCraft® European Black Elderberry Extract as a raw material so companies can produce products containing ElderCraft®. Because this website can be accessed from anywhere with Internet connectivity, the information presented here is intended for informational purposes only and does not necessarily satisfy regulatory requirements of all countries. Iprona AG makes no claims regarding the use of the finished products. All manufacturers and distributors with whom we do business are responsible for ensuring that the claims of their products comply with all regulatory requirements in effect in the locations in which their products are marketed and sold.

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